In addition, the treatment of ApoA 1 increased the expressions of PGC 1О± and its target genes Tfam, Ucp2 and SDHB ivermec In vivo results from B16F10 tumour bearing C57BL 6 mice revealed that these nanoconjugates were extensively accumulated inside the tumour and displayed a significant reduction in the tumour size in contrast to free PTX 63